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Since muscle loss is caused by a caloric deficit, in this sense, there's really no difference between preserving muscle during a normal caloric deficit
M.HammerD
For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]
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