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Subgroup analyses of CVOTs based on baseline metformin use in two previous meta-analyses, respectively, directed by Brendon L and Apostolos Tsapas have shown that SGLT-2i reduce the risk of MACE, HHF, or CV death, while GLP-1 RAs reduce MACE, cardiovascular mortality, and all-cause mortality regardless of metformin background treatment
California Medi-Cal (including Anthem managed care) ended weight loss coverage on 1/1/2026, projecting $85M in savings
doi: 10.1038/nature13270 79 MadirajuA
GH secretion was increased after CJC-1295 administration with preserved pulsatility confirming that continuous GHRH-receptor stimulation enhances both trough and mean GH secretion while maintaining the pulsatile architecture essential for physiological GH axis function
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