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Common B12 deficiency symptoms include fatigue, anxiety, depression, poor memory, confusion, brain fog, tingling or numbness in the extremities, zings or zapping feelings in the extremities, anemia, shortness of breath, muscle weakness, irritability, tender calves, pale complexion and more

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Tolerability (early human safety): Short human studies reported a placebo-like safety profile with no serious adverse events [5] [6]