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[10] [12] High-dose ascorbic acid may diminish the therapeutic effects of certain chemotherapeutic agents, such as bortezomib, due to its antioxidant properties

Safer DJ, Malever M

Known Side Effects Reported side effects are generally mild and infrequent: Injection site reactions: temporary redness, mild swelling, or tenderness Nausea: occasionally reported, usually mild and transient Dizziness: rare, typically with first doses Fatigue: some users report temporary tiredness Headache: infrequent, usually resolves quickly These effects typically diminish with continued use and rarely require treatment discontinuation

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