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Long-term open-label extension data covering up to 52 weeks of treatment demonstrated sustained efficacy and a consistent safety profile (PMID: 31599847)
No clinical evidence supports its use for muscle growth
Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo
(1997a)
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