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GHK has been shown to enhance extracellular matrix (ECM) activity in both dermal and pulmonary fibroblasts, with molecular systems involved including actin cytoskeletal remodeling and integrin signaling, with focal adhesion pathways facilitating attachment of fibroblasts to collagen
PMC 2690020
In biopsied photodamaged skin samples, GHK-Cu treatment led to notable collagen deposition and cell proliferation, confirming its role in active skin remodeling
This is a recognized scientific debate in senescence research
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