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Wegovy Tablets are licensed for adults (18 years and over) for weight management as an adjunct to a reduced-calorie diet and increased physical activity, where there is: An initial Body Mass Index (BMI) of 30 kg/m or greater (obesity), or An initial BMI of 27 kg/m to less than 30 kg/m (overweight) in the presence of at least one weight-related health problem, for example high blood pressure, type 2 diabetes, high cholesterol or obstructive sleep apnoea Efficacy has been demonstrated regardless of age, sex, race, ethnicity, baseline body weight, BMI and level of renal function, though results vary between individuals

4.7 Vascular niche and endothelial cell signaling In addition to angiogenesis, endothelial cells play an important role in the regulation of breast cancer progression by forming a vascular niche which promotes the survival, stemness, and metastatic spread of tumor cells (127)

Nevertheless, patients using insulin or sulfonylureas may require dose adjustments when initiating potent incretin-based therapy because improved glycemia and reduced caloric intake can increase hypoglycemia risk when combined with therapies that independently lower glucose

Besonders bei Ausdauerbelastungen, etwa beim Sport, ist dieser Mechanismus wichtig