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These improvements could be due to numerous reasons
Endosomal escape and intracellular delivery Efficient intracellular delivery remains a significant challenge in the development of GLP-1R-targeted nanomedicines, particularly for nucleic acid cargos such as small interfering RNA (siRNA) and mRNA that require cytosolic access to exert their therapeutic effects
Patients with obesity may be candidates if they meet specific body mass index (BMI) or body weight criteria
The issue that we have with liraglutide is its a once daily injection that went out the door as soon as there was a once a week injection
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