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Multiple transport mechanisms involved in the intestinal absorption of metformin: impact on the nonlinear absorption kinetics

Their use is rising rapidly, and with good reason: These medications have been shown to reduce blood sugar, improve fatty liver, GERD, sleep apnea, osteoarthritis, blood pressure, triglycerides, major adverse cardiovascular events, and even show potential benefits for conditions like alcohol use disorder (Mozaffarian et al., 2025