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5XFAD Ppar-null mice, developed earlier in-house (42), were maintained Tg for the 5XFAD mutations and homozygous for the Ppar -null allele through genotyping using PCR on genomic DNA isolated from tail biopsies and detected by primers listed in Supplemental Table 2
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DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) studied in sleep and neuroregulatory research
Results build gradually over a 12-week cycle
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