metformin and tirzepatide My - SURPASS-2: A Study of Versus Semaglutide Once Weekly as Add-on Therapy to in Participants With Type 2 Diabetes. #visualabstract #endocrinology #clinicaltrials Can Zepbound (tirzepatide) be co‑administered

Ive observed that there are 5 obstacles patients experience with these medications as treatments for obesity and diabetes: Cost of the meds Side effects and tolerability Fear of needles Concerns about safety The moral failing of needing a medication Oral GLP1 drugs like orforglipron (Foundayo) and Wegovy work almost as well as the injectable version of these drugs The FDA just approved oral Foundayo for the treatment of obesity based on the results of the ATTAIN-1 trial, recently published in NEJM

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Risk factors that matter most Not everyone on semaglutide faces the same blood clot risk

treated streptozotocin-induced DM rats with exenatide, a GLP-1R agonist, for 8 weeks and found that exenatide treatment attenuated the reduction in motor nerve conduction velocity and paw intraepidermal fibre density (50)