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Complete cessation typically results in gradual return to baseline over 4-8 weeks
In placental tissues obtained from offspring of obese parents, DNA hypermethylation dysregulated the expression of histone deacetylase 4, (HDAC4), which modulates fat cell expansion, promotes energy utilization and protects from excessive weight gain [174,175,176,177] This dysregulation could elevate metabolic disease risk in offspring later in life [174]
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