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Increasingly, human trials demonstrate distinct responder and non-responder subgroups, even when participants receive the same strain and dosage, with differences correlated to baseline microbial community structures, metabolic profiles, and gut transit characteristics (573)
68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components
doi: 10.1017/S0031182099004564 24 JemaM.FezaiM.BissingerR.LangF
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