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Based on the patients response to the medication and how they tolerate the side effects, healthcare providers may use their clinical judgment to adjust the dosing regimen to best suit their patient, Ngo-Hamilton adds
Patients should contact their GP or prescribing clinician if they experience : Severe or persistent diarrhoea lasting more than 48-72 hours despite conservative management Signs of dehydration , including reduced urine output, dark-coloured urine, dizziness, confusion, or persistent thirst Blood in stools or black, tarry stools (melaena) Severe abdominal pain , particularly if localised or accompanied by fever Unintentional weight loss beyond expected therapeutic effects Inability to maintain adequate oral fluid intake due to concurrent vomiting Urgent medical attention is required if patients develop symptoms suggestive of serious complications, including acute pancreatitis (severe upper abdominal pain radiating to the back, often with vomiting) or gallbladder disease (pain in the right upper abdomen, fever, or yellowing of the skin/eyes)
Dose increases are supposed to follow the slow titration schedule for a reason
Presented for research literature review only Herrera HO et al
