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Second, payer policies may continue to shape access even after lower-cost versions become available

Albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, orforglipron and semaglutide used in the clinic are monoGLP-1RAs, tirzepatide acts not only on GLP1R, but also on glucose-dependent receptors of insulinotropic peptide (GIP), and retatrutide is a triple agonist of GLP-1, GIP and glucagon receptors

Most community protocols use a 24-week staggered titration to reach maintenance, then run open-ended at maintenance with periodic re-evaluation

See also References 1 2 3 4 5 6 7 8 "Killer Klowns from Outer Space (1988)"