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Harms, N., Ras, J., Reijnders, W

Increased levels of corticotropin-releasing hormone or corticosterone/cortisol with FGF21 or FGF21 analog treatment have been reported in rodents, but not in non-human primates nor in any human studies (183, 293, 313)

Botulinum neurotoxin (BoNT) proteases 19,20 are in widespread clinical use and could be promising starting points for such a strategy in light of their catalytic mechanism, modular architecture 21 , intrinsic ability to self-deliver into target cells 22 and demonstrated evolvability 23,24,25

Before we consider how other radicals are derived from oxygen radicals, it is necessary to mention some normal physiological processes that lead to formation of oxygen radicals