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The signaling pathways in the GIT includes the complex enteric nervous system (ENS) that consist of two neural networks located in the submucosa layer and has pacemaker cells and controls i.e., motility via release of neurotransmitters based on the amino acid tryptophan associated neurotransmitter serotonin (5-HT: Serotonin, 5-hydroxytryptamine), dopamine and GABA

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Then there were these other small molecules that didn't have safety problems associated with them, so that meant that the entire field of obesity and big pharma died out for some time