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2.5 Post-GLP1 Use Case While no large trials directly study GLP1 tapering with Phentermine/Topiramate, clinical experience supports it because: Drug combination has a strong appetite suppressing profile It supports long-term maintenance (over 1 year) in trials like CONQUER and EQUIP The dual mechanism (appetite + craving reduction) makes it an ideal maintenance therapy 2.6 Common Side Effects from Phentermine/Topiramate (Qsymia ) Phentermine/Topiramate side effects have been well documented and are manageable for most people

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