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Phosphorylation of IRS-1 or IRS-2 activates phosphoinositol 3-kinase (PI3K)-PDK1-AKT signaling pathway, while phosphorylation of Shc leads to activation of RAS, RAF and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling pathway

Data availability The authors declare that data supporting the findings of this study are available within the article and its Supplementary Information files and from the corresponding author upon reasonable request

Knowing your dose is right, your IGF-1 is in range, and your body composition is actually changing is what turns it from an experiment into medicine