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Since our intrinsic-solubility-prediction models are entirely trained on values generated with Starling-predicted conversions, the error induced by using in silico p K a predictions likely outweighs any benefit of training on

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It depends on the person and tolerance of course, but in general the most tried and true studies when it comes to repeatable high impact with a proportional relative lack of side effects, but not none, was like three to six milligrams a kilogram