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Regarding safety profile, in phase 2 trials for obesity and diabetes, mazdutide was discontinued due to AE by 02% of participants and SAE experienced by up to 7% of participants with mazdutide 6 mg (Tables 2 and 3)
However, this broader action means a higher chance of gastrointestinal side effects early on
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A randomized controlled trial published in the New England Journal of Medicine demonstrated that tesamorelin significantly reduced visceral adipose tissue in patients with abdominal fat accumulation (Falutz et al., 2007)
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