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Altogether, these results demonstrate that CNS GIPR antagonism leads to body weight loss, and both central and systemic dosing of mGIPR-Ab can target the CNS to regulate body weight
Liraglutide 3.0 mg, although less effective than semaglutide 2.4 mg, still has the highest rate of serious side effects
This benefit may be related to the effects of the drug and the weight loss it promotes
Therefore, this review aims to synthesize the evidence on the mechanistic expansion of GLP-1RAs from metabolic regulators to systemic modulators of inflammation, autophagy, and organ protection, and explores their therapeutic repurposing across diseases
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