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Oral administration of ALC may be recommended due to its similar efficacy but easier administration

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Simultaneous quantification of these two oxidized metabolites by electrochemical HPLC assay demonstrated that human P450 2E1 selectively oxidizes APAP to NAPQI (determined as glutathione conjugate, GS-APAP), whereas human P450 2A6 selectively oxidizes APAP to 3-OH-APAP (Chen et al., 1998)

These results demonstrate the effectiveness and robustness of the hybrid approach in improving diagnostic accuracy