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Metformin, through the induction of 5' AMP-activated protein kinase and subsequently insulin sensitivity, has been widely used as a therapeutic agent in various conditions, including type 2 diabetes mellitus, PCOS and gestational diabetes (Reference Rice, Elia and Jawad42)

This has led researchers to investigate medications that modulate these systems, including the glucagon-like peptide-1 (GLP-1) receptor agonists originally developed for type 2 diabetes and obesity management

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These fluctuations are responsible for adverse side effects, including severe conditions like cancer