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Moderate inclusion levels are recommended to balance nutritional benefits with sensory acceptance
Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage
Notably, many polyphenols also exhibit circadian activity e.g., resveratrol can activate the SIRT1 pathway which influences the clock, and quercetin can modulate clock gene expression in cells
L., Spranger, J., & Arafat, A
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