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pancreatic islet preparations for insulin secretion analyses Cellular and Molecular Studies Cryo-electron microscopy structural determinations of receptor-peptide complexes G-protein coupling and cAMP signaling assays Gastric emptying studies in both animal models and human subjects Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite promising phase 2 clinical trial results, GLP3 faces substantial evidence gaps that require resolution before widespread clinical application becomes possible

Sannier A, Dupuis E, Berger AK, Bischofs C, Massy ZA, Seidowsky A

Mol Cell Endocrinol (2013) 366(2):21523

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