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The trial showed that tirzepatide achieved roughly 20% weight loss (about 50 pounds) versus 14% weight loss (33 pounds) with semaglutide. This significant difference prompted analysts to declare tirzepatide the winner. As a result, clinicians are updating treatment algorithms and patients on semaglutide are asking about switching
It's one component of a clinical program that includes dietitian-led nutrition counseling, continuous glucose monitoring when appropriate, and regular clinician check-ins
But that speed comes at the cost of a broader, less targeted effect and a higher incidence of side effects
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