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2020;319(6):E101930
Strategic Implications If validated in prospective randomized trials, GLP-1 receptor agonists could: Represent an adjunctive strategy in obesity-associated asthma Expand the therapeutic footprint of GLP-1s beyond metabolic disease Influence treatment guidelines in high-BMI asthma populations Given the rapid adoption of GLP-1 therapies globally, further investigation into respiratory benefits could have significant clinical and commercial implications
Mechanically, hyperinsulinemia stimulates liver fat accumulation, which secretes free fatty acid into blood vessels and conducts the deposition of the free fatty acid in the pancreas (Pinnick et al., 2008
Some Patients Stop After Reaching Their Goals Another possible explanation is that some individuals discontinue treatment after achieving meaningful weight loss or improved blood sugar control
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