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The study protocol was conducted according to the institutional and ethical guidelines of the care and use of laboratory animals, complied with the ARRIVE guidelines, and was approved by the ethical committee of the Faculty of Pharmacy, Ain Shams University (Egypt) (ENREC-ASU-number 133)
These findings are robust and supported by various predefined sensitivity tests and external data validation
In line with this study, in a double-blind, placebo-controlled RCT enrolling PCOS women with BMI 25 kg/m 2 , Nylander et al
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