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Animals tests for acute skin irritation assessment usually follow the Draize rabbit test while other accepted assays for skin sensitization include Local Lymph Node Assay (LLNA) and Guinea Pig Maximisation Test (GPMT)
Self-administration can carry risks such as infection, allergic reactions, improper dosing, pain, bruising, and unexpected side effects
Teshfam et al., 2010))
The central melanocortin system MC3R & MC4R receptors play a fundamental role in the control of feeding and body weight
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