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SKU: 11697498001) in a Precellys Evolution Touch homogenizer (Bertin Technologies, Rockville, MD, USA
Finally, the membranes were washed with TBST for 10 minutes 3 followed by incubation in secondary antibodies (1:10,000, Boster) for 1 hour at 37 C, visualized with ImageQuant LAS4000 system (GE Healthcare, USA)
Treatment with GLP-1RAs reduces expression of -smooth muscle actin (-SMA) and collagen type I in HSCs, thereby attenuating fibrogenesis ( /Smad and peroxisome proliferator-activated receptor gamma (PPAR), which regulate HSC activation and extracellular matrix (ECM) synthesis ( In vivo studies conducted on animal models of MASLD/MASH have reveal that GLP-1RAs can reduce liver fibrosis scores and collagen deposition, accompanied by decreased inflammatory infiltration and oxidative stress ( Beyond anti-fibrotic effects, GLP-1RAs promote hepatocyte regeneration and repair
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