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Until durability data are available, chronic maintenance therapy analogous to treatment paradigms for other chronic liver conditions is likely required to sustain hepatic benefits
The pharmacokinetic parameters included area under the curve plasma concentrations (AUC), maximal plasma concentration (C max ), time to C max , half-life (t 1/2 ), and clearance
Deficiency can cause fatigue, brain fog, and mood changes
Patients who remain on these doses indefinitely are receiving a fraction of the proven benefit while still assuming the commitment of weekly injections
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