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In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)
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Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice
Amount and diversity of volatile organic compounds The number and total amount of VOCs were higher in the cultures grown in anaerobiosis than in those grown in aerobiosis for all 3 species, and the difference was significant only for odorous VOCs (Fig
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