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The accumulation factor (R 1015 for semaglutide with once-daily dosing) describes the ratio of steady-state exposure to single-dose exposure, not a process of unlimited accumulation
La evidencia clnica directa se limita actualmente a una serie no controlada de cinco pacientes tratadas con exenatida y a una comunicacin en formato resumen sobre una paciente tratada con tirzepatida 8,9
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(9) M Moon, H Geun Kim, L Hwang, J-H Seo, et al (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinsons disease by blocking microglial activation Neurotoxicity Research, 2009 May, 15 (Issue 4), Pages 332-47
