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Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
doi:10.1016/j.foodchem.2013.05.017
After reconstituting with bacteriostatic water , store at 2-8 degrees C (standard refrigerator temperature) and use within 28-30 days
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