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Increased risk of testicular germ cell cancer among infertile men
These effects were observed with central, but not peripheral, administration of the agonist and antagonist, suggesting receptor expression on the luminal, CSF-facing side of the choroid plexus, which aligned with GLP-1R-mediated modulation of luminally-expressed transporters in excised choroid plexus
This article examines the pharmacology of both agents, safety considerations, clinical evidence gaps, and practical guidelines for patients and clinicians considering this combination under medical supervision
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