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Metabolic conditions in midlife, such as obesity and diabetes, are well-established and modifiable risk factors for the development of dementia (as highlighted by the Lancet Commission on dementia risk factors)

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Zhang D, Zhang X, Tian L, Ye F, Huang X, Zeng Y, Fan M (2013) Seasonal and Spatial dynamics of trace elements in water and sediment from Pearl river Estuary, South China

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Before their cellular effects can be fully explained, more thorough studies are required to fully understand the signaling pathways affected by dual- and triagonism

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He adds that there are potential health benefits beyond the scale

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