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Schoderbeck M, Auer B, Legenstein E, et al
Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events
Folinic Acid Can Cross the Blood-Brain Barrier Unlike folic acid (which must be converted to 5-MTHF and is poorly transported when FR is blocked), folinic acid (5-formyl-THF) can be directly converted to 5-MTHF
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