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Mechanistic exploration suggested that pamidronate and clodronate markedly inhibit IGF-1-induced HIF-1 protein accumulation and VEGF expression in breast cancer cells via the PI-3K/AKT/mTOR signaling pathway and ultimately eliminate IGF-1-induced tumor angiogenesis in vivo and in vitro (38)
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Cardiovascular Protection : Emerging research suggests that GLP-1 receptor agonists may have cardioprotective effects, with studies examining their potential to reduce the risk of cardiovascular events in patients with type 2 diabetes or obesity
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