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Preclinical findings show that these medications can reduce drug use and craving by modulating reward pathways, stress responses, and cognitive functions
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Specifically, RNA interference (RNAi) utilizes small interfering RNA (siRNA) or short hairpin RNA (shRNA) to precisely bind to the messenger RNA (mRNA) of DAMP receptor genes via base-complementary pairing
Clinical implication The updated FDA labeling for liraglutide and semaglutide highlights the importance of monitoring depressive symptoms or suicidal thoughts, suggesting treatment discontinuation if such ideations occur [87,88]
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