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Although these findings do not directly address PCOS or redox homeostasis, they provide a proof-of-concept for the potential of network-targeted strategies in female reproductive disorders (Fig
Notably, this protective effect occurred through mechanisms independent of changes in muscle oxidative metabolism or fatigue resistance, distinguishing IGF-1 LR3's mechanism from native IGF-1
Tirzepatide was the first dual GLP-1/GIP agonist to reach approval, and the published SURMOUNT-1 trial showed that adding GIP to GLP-1 produces additive metabolic effects
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