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By tagging the substrates with ubiquitin, E3 ligases provide a platform for protein-protein interactions that can modulate the activity, localization or interaction of the target proteins, thereby triggering different biological signals to regulate a variety of cellular processes including cell cycle, cell division, stress response, DNA repair and apoptosis etc 1,2,3,4
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Cauli O, Rodrigo R, Piedrafita B, Llansola M, Mansouri MT, Felipo V
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