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are making people less hungry by altering the hunger hormones and slowing down the gut so food doesnt move as fast, thus keeping people feeling fuller, for longer
Adding a DPP-4 inhibitor to a potent GLP-1 agonist like semaglutide or tirzepatide may provide minimal additional glucose control while raising the risk of side effects such as nausea, vomiting, and pancreatitis-related concerns
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While the papers authors note that many of those improvements were due to taking weight off the affected knees, they also postulate that semaglutides known anti-inflammatory effects played a role as well
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