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MOTS-c Purported Benefits: Improved insulin sensitivity Enhanced energy metabolism Potential anti-obesity effects Potential Risks and Complications: Metabolic Dysregulation: May cause hypoglycemia or hyperglycemia, leading to serious health issues
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Some men may feel pain or discomfort in their lower back, hips, or pelvis
In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (65)
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