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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion ( Lipotoxicity induced by saturated free fatty acids plays a vital role in renal injury in obese patients ( There is little research on the weight loss effect of EX on simple obesity patients, and more clinical trials are conducted on patients with T2DM
Injections of concentration series of these three albumin variants confirmed that they bound FcRn with similar kinetics and affinity to that of WT albumin (Table 1, Supplementary Fig
Conventional drugs often arent enough to ease their effects
Cellular GSH level monitoring using FreSHtracer probe The detailed methods of synthesizing FreSHtracer probe are explained in the previous study [19]
