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incorporated CAPE and piceatannol (PIC), another polyphenol found in grapes and wine, into albumin NPs to determine how well they work as therapeutic agents in C57BL mice with experimental colitis (Tambuwala et al., 2019)
Permeability to proteins and to large lipoid molecules
More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]
The data showed that with weekly administration, it normalized glucose tolerance and led to weight loss by the reduction of food intake and increased energy expenditure in obese mice [41]
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