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Magliano DJ, Islam RM, Barr ELM et al (2019) Trends in incidence of total or type 2 diabetes: systematic review

In clinical trials, retatrutide resulted in an average weight loss of approximately 5% of body weight in the first month, with many experiencing an appetite reduction within a few weeks

Common GLP-1 side effects include: Nausea Vomiting Diarrhea or constipation Abdominal discomfort Fatigue Acid reflux/heartburn Dizziness (related to dehydration) To improve tolerability, healthcare providers typically start patients on a low dose and increase it gradually