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The combination of genetic models, controlled diets, detailed pharmacological dosing, and multi-level analyses provided a comprehensive framework for understanding the mechanisms underlying cagrilintides central regulation of energy balance [2]

The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

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