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Slow titration of dose can help, as can dietary adjustments. The recent mast cell paper suggested: significantly lower doses of GLP-1RAs than presently used as starting doses for T2DM and obesity therapy might be sufficient, and even optimal, for MCAS
Macartney G, Zvonar, R., McDiarmid, S., Harris, B, and Laplante, J
Harm Reduction An approach to substance use that focuses on minimizing negative consequences rather than demanding complete abstinence
& Deckelbaum, R
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