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Usage of the CCR2/CCR5 inhibitor cenicriviroc was shown to reduce two-year liver fibrosis progression in a clinical trial of MASH (NCT02217475)
Blood sugar regulation: Semaglutide causes enhanced insulin secretion, reduced glucagon production, improved insulin sensitivity in peripheral tissues, and decreased hepatic glucose output, which all have a positive effect on blood sugar levels
These findings establish the mechanistic basis for the compound and provide proof of concept for its metabolic effects
All measures were collected on the third day of each challenge week
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